Electrochemical behavior of palmatine and its sensitive determination based on an electrochemically reduced l-methionine functionalized graphene oxide modified electrode

Analyst Pub Date: 2015-10-13 DOI: 10.1039/C5AN01770J

Abstract

A new and sensitive voltammetric sensor for palmatine, based on an electrochemically reduced L-methionine functionalized graphene oxide modified glassy carbon electrode (L-Met-ERGO/GCE), is reported. The electrochemical characteristics of palmatine at the proposed sensor were studied systematically and some dynamic parameters were calculated for the first time. A reasonable reaction mechanism for palmatine on the L-Met-ERGO/GCE electrode was proposed and discussed, and this could be a reference for the pharmacological action of palmatine in clinical study. Under optimized conditions, the peak current had a linear relationship with palmatine concentration in the range of 1 × 10?7 to 5 × 10?5 mol L?1 with a detection limit of 6 × 10?8 mol L?1. Additionally, the proposed method was also used to detect palmatine in human urine samples, medicinal tablets and the Chinese herb Fibraurea recisa Pierre with satisfactory results.

Graphical abstract: Electrochemical behavior of palmatine and its sensitive determination based on an electrochemically reduced l-methionine functionalized graphene oxide modified electrode
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