Efficient synthesis of a new, highly versatile chiral derivatizing agent, α-cyano-α-fluoro-p-tolylacetic acid (CFTA)
Chemical Communications Pub Date: 1900-01-01 DOI: 10.1039/A707755F
Abstract
The new and versatile chiral derivatizing agent, α-cyano-α- fluoro-p-tolylacetic acid (CFTA), has been efficiently synthesized in optically pure form by Candida rugosa lipase-mediated kinetic resolution of racemic CFTA ethyl ester, the latter being readily prepared by fluorination of ethyl α-cyano-p-tolylacetate with FClO3.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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