Efficient syntheses of pterulone, pterulone B and related analogues?

Organic & Biomolecular Chemistry Pub Date: 2003-10-23 DOI: 10.1039/B306356A

Abstract

An efficient synthesis of the three halogenated naturally occurring products, pterulone (2), pterulone B (3) and alcohol 5, and of a wide range of related unnatural analogues has been achieved starting from the two readily available 1-benzoxepine sulfonyl-containing intermediates 6a and 6b. The biological activities of pterulone and some of the synthesized analogues were tested against a wide spectrum of phytopathogenic fungi.

Graphical abstract: Efficient syntheses of pterulone, pterulone B and related analogues
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