Demonstration of the difference in binding affinity between the two binding sites of the ristocetin A asymmetric dimer

Chemical Communications Pub Date: 1900-01-01 DOI: 10.1039/CC9960000101

Abstract

The titration of 13C labeled N-acetyl-D-ala-D-ala with the glycopeptide antibiotics ristocetin A and eremomycin, monitored by 13C NMR spectroscopy, demonstrates that the two distinct binding sites of the ristocetin A asymmetric dimer have different affinities, whereas those of eremomycin show no detectable difference.

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