Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization?
Organic & Biomolecular Chemistry Pub Date: 2018-09-15 DOI: 10.1039/C8OB02012D
Abstract
An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydro-quinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free conditions, wide substrate scope, and high step- and atom-economy.
![Graphical abstract: Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization](http://scimg.chem960.com/usr/1/C8OB02012D.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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