Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives?
Organic & Biomolecular Chemistry Pub Date: 2019-02-06 DOI: 10.1039/C8OB03048K
Abstract
A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki–Miyaura coupling. The chiral-bridged biphenyl monophosphine ligand L1 was found to be much more effective in the reaction enantioselection than its counterpart binaphthyl monophosphine ligands.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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