Enantioselective halogenation reactions

Chemical Communications Pub Date: 2004-03-08 DOI: 10.1039/B317004G

Abstract

Stereoselective halogenation reactions, in particular fluorinations, are not everyday's chemistry despite the fundamental and still increasing significance of fluorinated molecules, e.g., for the life science industry. The selective fluorination of a bioactive compound can be generally beneficial in terms of a possible increased intrinsic activity, enhanced chemical and metabolic stability, and improved pharmacokinetics. It is clear that more efficient and selective methodologies for the introduction of fluorine into organic molecules are still needed. We review in this article latest progresses in the area of enantioselective fluorinations, with particular emphasis on new catalytic reactions and extend our discussion to similar reactions involving the other halogens.

Graphical abstract: Enantioselective halogenation reactions
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