Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis?
Chemical Communications Pub Date: 2020-02-27 DOI: 10.1039/D0CC00767F
Abstract
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel–Crafts acylation.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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