Direct synthesis of pyridines and quinolines by coupling of γ-amino-alcohols with secondary alcohols liberating H2 catalyzed by ruthenium pincer complexes?

Chemical Communications Pub Date: 2013-05-28 DOI: 10.1039/C3CC43227K

Abstract

A novel, one-step synthesis of substituted pyridine- and quinoline-derivatives was achieved by acceptorless dehydrogenative coupling of γ-aminoalcohols with secondary alcohols. The reaction involves consecutive C–N and C–C bond formation, catalyzed by a bipyridyl-based ruthenium pincer complex with a base.

Graphical abstract: Direct synthesis of pyridines and quinolines by coupling of γ-amino-alcohols with secondary alcohols liberating H2 catalyzed by ruthenium pincer complexes
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