Covalent versus non-covalent (biocatalytic) approaches for enantioselective sulfoxidation catalyzed by corrole metal complexes?

Catalysis Science & Technology Pub Date: 2011-05-13 DOI: 10.1039/C1CY00046B

Abstract

Oxidation of thioanisoles, catalyzed by chiral manganese(III) and iron(III) corroles, provides the corresponding sulfoxides in moderate chemical yields and low enantioselectivities. Biocatalysis by non-chiral albumin-associated manganese(III) corroles proceeds much better and allows for the enantioselective synthesis of the pharmacologically important R-modafinil, in 88% yield and 73% ee.

Graphical abstract: Covalent versus non-covalent (biocatalytic) approaches for enantioselective sulfoxidation catalyzed by corrole metal complexes
Recommended Literature