A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines??

Organic & Biomolecular Chemistry Pub Date: 2012-03-07 DOI: 10.1039/C2OB25327E

Abstract

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.

Graphical abstract: A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines
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