Direct amidation of the phenylalanine moiety in short peptides via Pd-catalyzed C–H activation/C–N formation?
Organic Chemistry Frontiers Pub Date: 2014-11-28 DOI: 10.1039/C4QO00282B
Abstract
Selective modifications of life's basic components, such as polypeptides, are of great importance in both chemistry and biology. Herein, we have developed an unprecedented intramolecular amidation of the phenylalanine moiety in dipeptides via Pd-catalyzed sp2 C–H activation and C–N formation.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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