DOTMA-based amides (DOTMAMs) as a platform for the development of PARACEST MRI contrast agents?
RSC Advances Pub Date: 2016-06-24 DOI: 10.1039/C6RA11741D
Abstract
A synthetic methodology leading to previously unknown DOTMA-based secondary amides (DOTMAMs) has been developed. Alkylation of cyclen with L-lactic acid-derived pseudohalides was used as a key step affording the alkyl- and aryl-decorated DOTMAMs. Amino acid-decorated DOTMAMs were obtained via peptide coupling between DOTMA and protected amino acids. Metallation of the DOTMAMs ligand with Tm3+ gave complexes exhibiting proximal amide proton based paramagnetic CEST effects at <?50 ppm relative to water.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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