A highly enantioselective catalytic Strecker reaction of cyclic (Z)-aldimines?

Chemical Communications Pub Date: 2012-03-20 DOI: 10.1039/C2CC31001E

Abstract

A range of 3H-indoles and 2H-benzo[b][1,4]thiazines smoothly undergo asymmetric Strecker reaction with ethyl cyanoformate in the presence of a Cinchona alkaloid-based thiourea catalyst at 10 °C to give structurally diverse nitrogen-containing heterocycles in good to excellent yields and with excellent ee.

Graphical abstract: A highly enantioselective catalytic Strecker reaction of cyclic (Z)-aldimines
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