Copper-mediated cyanation of indoles and electron-rich arenes using DMF as a single surrogate?

Organic & Biomolecular Chemistry Pub Date: 2015-06-30 DOI: 10.1039/C5OB01244A

Abstract

The copper-mediated cyanation of indoles with DMF as a single surrogate has been realized. This approach could be applied for the cyanation of some electron-rich arenes and aryl aldehydes as well. Aryl aldehydes were demonstrated to be the key intermediates in the cascade process of cyanation of indoles and electron-rich arenes.

Graphical abstract: Copper-mediated cyanation of indoles and electron-rich arenes using DMF as a single surrogate
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