Direct sulfonylation of anilines mediated by visible light?

Chemical Science Pub Date: 2017-11-16 DOI: 10.1039/C7SC03891G

Abstract

Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the utility of the method by the late-stage functionalization of drugs. Key features of the method are the straightforward generation of sulfonyl radicals from bench-stable sulfinate salts and the use of simple aniline derivatives as convenient readily available coupling partners.

Graphical abstract: Direct sulfonylation of anilines mediated by visible light
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