A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions?

Chemical Communications Pub Date: 2010-09-20 DOI: 10.1039/C0CC02823A

Abstract

A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented. The classical issue of lack of stereoselectivity in Ugi- and Passerini-type reactions is circumvented. The atom economic and convergent nature of the synthetic strategy require only very limited use of protective groups.

Graphical abstract: A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions
Recommended Literature