Directed studies towards the total synthesis of (+)-13-deoxytedanolide: simple and convenient synthesis of the C8–C16 fragment?

Organic & Biomolecular Chemistry Pub Date: 2013-05-22 DOI: 10.1039/C3OB40674A

Abstract

A straightforward synthesis of the enantioenriched C8–C16 south part of (+)-13-deoxytedanolide has been reported. The strength of this approach relies on the preparation of similar functionalized fragments via the transformation of a unique dihydrofuran building block through a 1,2-metallate rearrangement.

Graphical abstract: Directed studies towards the total synthesis of (+)-13-deoxytedanolide: simple and convenient synthesis of the C8–C16 fragment
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