Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures
Organic & Biomolecular Chemistry Pub Date: 2012-06-28 DOI: 10.1039/C2OB25802A
Abstract
A rapid and efficient protocol to afford the title compound 2-[18F]-fluoro-2,2-difluoroethyl tosylate ([18F]7b) is described. Starting from [18F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([18F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.
![Graphical abstract: Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures](http://scimg.chem960.com/usr/1/C2OB25802A.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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