Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions?

Organic & Biomolecular Chemistry Pub Date: 2013-01-16 DOI: 10.1039/C3OB27433K

Abstract

An efficient and direct use of formamides as amino group sources for the synthesis of α-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of acetophenones with formamides and generated the desired products in good yields in the presence of t-BuOOH/I2/PhCO2H.

Graphical abstract: Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions
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