Development of a chemical probe for identifying protein targets of α-oxoaldehydes?

Chemical Communications Pub Date: 2013-03-25 DOI: 10.1039/C3CC41099D

Abstract

The development of a chemical probe for identifying the protein targets of reactive electrophilic α-oxoaldehydes such as methylglyoxal is presented. The probe is evaluated against methylglyoxal using human serum albumin as well as using living cells and lysates.

Graphical abstract: Development of a chemical probe for identifying protein targets of α-oxoaldehydes
Recommended Literature