A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction?

Green Chemistry Pub Date: 2011-06-16 DOI: 10.1039/C1GC15223H

Abstract

A grinding-induced catalyst- and solvent-free domino multicomponent reaction for the synthesis of 1,4-dihydropyridines has been developed using aldehydes, amines, DEAD (diethyl acetylenedicarboxylate), and malononitrile/ethyl cyanoacetate. The synthesized 1,4-dihydropyridines were efficiently converted into novel tacrine analogs 7a–7e using micelle-promoted microwave irradiation.

Graphical abstract: A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction
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