Dinuclear zinc-catalyzed asymmetric Friedel–Crafts alkylation/cyclization of 3-aminophenols with α,α-dicyanoolefins?
Chemical Communications Pub Date: 2021-08-31 DOI: 10.1039/D1CC04177K
Abstract
An enantioselective Friedel–Crafts alkylation/cyclization tandem reaction of 3-aminophenols with α,α-dicyanoolefins has been performed successfully using a chiral dinuclear zinc catalyst, leading to a range of chiral 2-amino-4H-chromenes (up to 98% yield and >99% ee). To the best of our knowledge, this is the first asymmetric example of the dinuclear zinc-catalysed functionalization of aromatic C(sp2)–H bonds.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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