Drug release from hydrazone-containing peptide amphiphiles?

Chemical Communications Pub Date: 2011-06-15 DOI: 10.1039/C1CC12570B

Abstract

Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.

Graphical abstract: Drug release from hydrazone-containing peptide amphiphiles
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