Domino Heck/Hiyama cross-coupling: trapping of the σ-alkylpalladium intermediate with arylsilanes?
Organic & Biomolecular Chemistry Pub Date: 2021-04-16 DOI: 10.1039/D1OB00595B
Abstract
A palladium-catalyzed domino Heck cyclization/Hiyama coupling reaction by the trapping of the σ-alkylpalladium intermediate with arylsilanes is described. A wide range of aryl-tethered alkenes and arylsilanes are all compatible with the reaction conditions. This approach shows good yields and excellent functional group tolerance, presenting a more practical and sustainable alternative to the conventional domino Heck cyclization/Suzuki coupling reaction.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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