A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide?

Chemical Communications Pub Date: 2021-05-26 DOI: 10.1039/D1CC02665H

Abstract

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach to label urea derivatives with all carbon isotopes, including 14C and 11C, based on a Staudinger aza-Wittig sequence. It provides access to all aliphatic/aromatic urea combinations.

Graphical abstract: A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide
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