Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans?
Organic & Biomolecular Chemistry Pub Date: 2018-06-19 DOI: 10.1039/C8OB01326H
Abstract
By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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