Direct synthesis of ortho-methylthio allyl and vinyl ethers via three component reaction of aryne, activated alkene and DMSO?
Organic & Biomolecular Chemistry Pub Date: 2020-03-20 DOI: 10.1039/D0OB00275E
Abstract
A synthetic strategy has been developed for the direct synthesis of ortho-methylthio allyl and vinyl ethers via three-component reaction of in situ generated aryne, activated alkene and DMSO. This reaction proceeds via several bond cleavage and bond formation processes in a single operation. Mechanistic studies reveal that DMSO served as both a methylthiolating agent and an oxygen source. This synthetic method provides a wide range of ortho-methylthio-substituted arenes in good yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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