Direct access to substituted benzo[b]carbazoles through cascade annulation of 2-vinylbenzaldehydes with indoles?
Chemical Communications Pub Date: 2019-02-14 DOI: 10.1039/C8CC10253H
Abstract
A highly efficient palladium-catalyzed cascade annulation of 2-vinylbenzaldehydes with indoles has been achieved to afford 6-(3-indolyl)benzo[b]carbazoles under mild conditions in good yield and with excellent regioselectivity. Mechanistic investigations reveal that the reaction proceeds via double addition of indoles, unexpected intramolecular 1,4-aryl and 1,2-hydrogen migrations, and oxidative aromatization.
![Graphical abstract: Direct access to substituted benzo[b]carbazoles through cascade annulation of 2-vinylbenzaldehydes with indoles](http://scimg.chem960.com/usr/1/C8CC10253H.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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