Construction of an all-carbon quaternary stereocenter by organocatalytic enantioselective α-functionalization of α-substituted β-ketocarbonyls with electron deficient vinylarenes?
Chemical Communications Pub Date: 2015-06-01 DOI: 10.1039/C5CC03562G
Abstract
A chiral amine catalyzed enantioselective α-functionalization of α-substituted β-ketocarbonyls with electron-deficient vinylarenes has been developed to construct the dicarbonyl products with the formation of a chiral all-carbon quaternary stereocenter. The products can be used for the efficient synthesis of useful but challenging chiral quaternary centered pyrazolones.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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