Design for carbon–carbon bond forming reactions under ambient conditions?

RSC Advances Pub Date: 2016-06-28 DOI: 10.1039/C6RA14399G

Abstract

The carbon–carbon (C–C) bond forms the ‘backbone’ of nearly every organic molecule, and lies at the heart of the chemical sciences! This transformation has always been one of the most useful and fundamental reactions in the development of organic chemistry. Currently, the concept of ‘green chemistry’ is globally acclaimed and has already advanced quite significantly to emerge as a distinct branch of chemical sciences. Among the principles of ‘green chemistry’, one principle is dedicated to the “design of energy efficiency” – that is to develop synthetic strategies that require less/minimum amounts of energy to carry out a specific reaction with optimum productivity. And the most effective way to save energy is to develop strategies/protocols that are capable enough to carry out the transformations at ambient temperature and pressure! As part of the on-going developments in green synthetic strategies, designing for reactions under ambient conditions coupled with other green aspects is, thus, an area of current choice. This review is aimed at offering an up-to-date development on the design of carbon–carbon bond forming protocols to access a wide variety of organic molecules of topical significance under ambient conditions. The account highlights the brilliant applications of reaction conditions such as the use of solvents or no solvent, catalysts or no catalyst, and the use of green tools like ball-milling, ultrasonication and visible light in achieving the goal!

Graphical abstract: Design for carbon–carbon bond forming reactions under ambient conditions
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