Cu-catalyzed selective cascade sp3 C–H bond oxidative functionalization towards isoxazoline derivatives?
Chemical Communications Pub Date: 2015-03-04 DOI: 10.1039/C5CC01004G
Abstract
The first Cu-catalyzed cascade sp3 C–H bond oxidative functionalization of the 2-ethylazaarenes has been developed. The two different sp3 C–H bonds in 2-ethylazaarenes are selectively oxidized and four new types of bonds (C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
O, CN, C–C, C–O) are constructed in one operation. Starting from the simple substrates and cheap nitro source, this reaction provides an efficient approach to produce new kinds of isoxazolines.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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