Diastereoselective synthesis of (±)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA
Organic & Biomolecular Chemistry Pub Date: 2006-06-01 DOI: 10.1039/B604002K
Abstract
A divergent synthesis of both diastereoisomers of (±)-(3-aminocyclopentane)alkylphosphinic acid is described. Both diastereoisomers are obtained in 5 steps from the key (±)-(3-hydroxycyclopent-1-ene)alkylphosphinate esters which are prepared via a palladium catalysed C–P bond forming reaction.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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