Concise total synthesis of (±)-aspidospermidine?
Organic & Biomolecular Chemistry Pub Date: 2015-03-24 DOI: 10.1039/C5OB00228A
Abstract
(±)-Aspidospermidine (1) has been synthesized from the commercially available 2,3-dihydro-1H-carbazol-4(9H)-one 6 in 10 steps with 20% overall yield. The key step of the strategy is a one-pot carbonyl reduction/iminium formation/intramolecular conjugate addition reaction that may be applied for the synthesis of other Aspidosperma alkaloids.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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