Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis??

Dalton Transactions Pub Date: 2012-11-28 DOI: 10.1039/C2DT31782F

Abstract

The cyclic peptide gramicidin S was used as a rigid template to provide novel peptide-based bisphosphine ligands for transition metal catalysis. Two bisphosphine-coordinated Rh(I) complexes allowed asymmetric hydrogenation with 10–52% ee and the corresponding Pd(II) analogues catalysed asymmetric allylic alkylation with 13–15% ee.

Graphical abstract: Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis
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