Determination of probenecid in serum by high-performance liquid chromatography
ANALYSTANALYST Pub Date: DOI: 10.1039/AN9780300492
Abstract
The determination of probenecid in serum samples by using high-performance liquid chromatography is described. The method gives satisfactory results over the normal therapeutic range, namely up to 150 μg ml–1 of probenecid in serum, and is not affected by metabolites of the drug. The method does not require derivatisation of the drug, as in gas-liquid chromatographic procedures, and is less subject to interferences than spectrophotometric procedures. It has been used in analysis of several hundred serum samples and has given a satisfactory performance in respect of precision and accuracy.
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CAS no.: 89640-58-4
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