Csp3–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines?
Chemical Communications Pub Date: 2018-07-12 DOI: 10.1039/C8CC04936J
Abstract
A series of tunable iminium ions, generated in situ by the condensation of 4-trifluoromethyl-p-quinols with cyclic amines, can lead to the divergent synthesis of trifluoromethylated arylamines in a single step via redox-neutral isomerization. The direct α- and β-functionalization of saturated amines can be achieved regioselectively under mild conditions.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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