Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts?

Organic & Biomolecular Chemistry Pub Date: 2011-05-18 DOI: 10.1039/C1OB05313B

Abstract

Coupling reaction between electron-rich 2-morpholino-4(3H)-pyrimidinone and nucleophilic side chains of several natural α-amino acids promoted by phosphonium salt has been developed to prepare new optically active pyrimidin-4-yl amino acids. The best results were obtained using a two-step method through the easily available benzotriazolyl-1-oxy intermediate. A detailed optimization study of this reaction is discussed.

Graphical abstract: Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts
Recommended Literature