Copper–TEMPO-catalyzed synthesis of α-ketoamides via tandem sp3C–H aerobic oxidation and amination of phenethyl alcohol derivatives?
Organic & Biomolecular Chemistry Pub Date: 2016-08-17 DOI: 10.1039/C6OB01387B
Abstract
An efficient copper–TEMPO-catalyzed one-pot synthesis of α-ketoamides from phenethyl alcohol derivatives was developed firstly. Moreover, molecular oxygen in open air was employed as the oxidant with a broad substrate scope, which makes this methodology more practical. Based on some control experiments, a plausible mechanism was proposed.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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