Copper-catalyzed N-arylation and aerobic oxidation: one-pot synthesis of tetrahydroisoquinolino[2,1-a]quinazolinone derivatives?
RSC Advances Pub Date: 2013-11-08 DOI: 10.1039/C3RA44975K
Abstract
An efficient and practical copper-catalyzed one-pot method for synthesis of tetrahydroisoquinolino[2,1-a]quinazolinone derivatives has been developed, and the corresponding target products were prepared in moderate to good yields. The one-pot approach underwent sequential copper-catalyzed N-arylation, intramolecular aerobic oxidative cyclization, and the newly synthesized products provided diverse structures for screening of biological molecules.
![Graphical abstract: Copper-catalyzed N-arylation and aerobic oxidation: one-pot synthesis of tetrahydroisoquinolino[2,1-a]quinazolinone derivatives](http://scimg.chem960.com/usr/1/C3RA44975K.jpg)
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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