Design of tumor-homing and pH-responsive polypeptide–doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects?
Chemical Communications Pub Date: 2015-06-11 DOI: 10.1039/C5CC04035C
Abstract
Tumor-homing and pH-responsive polypeptide–drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine cancer model, these nanoparticles show significantly better anti-tumor efficacy and less systemic toxicity than not only free drugs, but also polypeptide–drug nanoparticles without the tumor-homing function.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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