Copper powder-catalyzed chelation-assisted cascade reaction of o-chloroarylacetic acids with amines under solvent- and ligand-free conditions: synthesis of oxindoles?
RSC Advances Pub Date: 2017-09-21 DOI: 10.1039/C7RA08123E
Abstract
An efficient method to construct oxindole scaffolds from o-chloroarylacetic acids/esters with amines has been explored. This cascade protocol involves the in situ generation of o-aminoarylacetic acid derivatives by the copper powder catalyzed and weak O-chelation assisted Ullmann amination of unactivated C–Cl bonds under air, and solvent-/ligand-free conditions followed by annulative N-acylation.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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