Decarboxylation of α,β-unsaturated aromatic lactones: synthesis of E-ortho-hydroxystilbenes from 3-arylcoumarins or isoaurones?

Green Chemistry Pub Date: 2017-12-20 DOI: 10.1039/C7GC02994B

Abstract

A simple and environmentally friendly strategy for the synthesis of E-ortho-hydroxystilbenes has been established. Two kinds of α,β-unsaturated aromatic lactones, i.e. the 3-arylcoumarins and the isoaurones, could both readily undergo a cascade hydrolyzation/decarboxylation reaction in the presence of KOH in ethylene glycol to afford the desired E-ortho-hydroxystilbenes in moderate to high yields.

Graphical abstract: Decarboxylation of α,β-unsaturated aromatic lactones: synthesis of E-ortho-hydroxystilbenes from 3-arylcoumarins or isoaurones
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