Copper-catalyzed aerobic oxidative domino cyclization of methyl azaarenes with 6-amino-pyrimidine-2,4-diones and pyrazol-5-amines: access to dipyrimidine/dipyrazolo-fused pyridines?
Organic Chemistry Frontiers Pub Date: 2021-03-15 DOI: 10.1039/D0QO01588A
Abstract
An aerobic copper-catalyzed oxidative domino cyclization of methyl azaarenes with 6-amino-pyrimidine-2,4-diones and pyrazol-5-amines has been developed, which enables access to dipyrimidine/dipyrazolo-fused pyridines. Cu(OTf)2 is used as a transition-metal catalyst. The oxidative annulation procedure exhibits excellent catalytic efficiency, high functional group compatibility and broad substrate scope, such as methyl quinolines, 2-methyl quinoxaline, 2-methyl benzo[f]quinoline, 2-methyl benzothiazole, 2-methyl benzoxazole and methyl pyridines.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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