Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C–H activation?
RSC Advances Pub Date: 2016-09-14 DOI: 10.1039/C6RA20732D
Abstract
A one-pot oxidative amidation of both aliphatic and aromatic alcohols with N-chloramines, prepared in situ from many types of primary and secondary amines, was developed. This cross-coupling reaction integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation. And it was green, simple and convenient, which has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The practical value of this method is highlighted through the synthesis of a high-profile pharmaceutical agent, acetylprocainamide.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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