A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy?

Chemical Communications Pub Date: 2012-09-26 DOI: 10.1039/C2CC34297A

Abstract

A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.

Graphical abstract: A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy
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