Copper-catalyzed tandem aerobic oxidative cyclization for the synthesis of 4-cyanoalkylpyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclobutanone oxime esters?
Chemical Communications Pub Date: 2018-08-30 DOI: 10.1039/C8CC06256K
Abstract
A copper-catalyzed tandem ring-opening/cyclization reaction for the synthesis of 4-cyanoalkylpyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclobutanone oxime esters has been developed. This reaction involves C–C bond cleavage and C–C and C–N bond constructions with good functional group tolerance. A wide range of products are obtained in moderate to good yields under mild conditions.
![Graphical abstract: Copper-catalyzed tandem aerobic oxidative cyclization for the synthesis of 4-cyanoalkylpyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclobutanone oxime esters](http://scimg.chem960.com/usr/1/C8CC06256K.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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