Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction?

Green Chemistry Pub Date: 2015-02-02 DOI: 10.1039/C4GC02408G

Abstract

This work reports a copper-catalyzed novel protocol for the tandem synthesis of 2-benzimidazolone derivatives from dimethyl carbonate (DMC) and various 2-nitroanilines by using polymethylhydrosiloxane (PMHS) as an inexpensive, stable and environmentally benign reducing agent. This methodology is applicable for the preparation of a broad range of biologically active 2-benzimidazolone derivatives with a good scope in good to excellent yields.

Graphical abstract: Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction
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