Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones?
Catalysis Science & Technology Pub Date: 2015-04-30 DOI: 10.1039/C5CY00422E
Abstract
Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones catalyzed by the Cu(OAc)2/FOXAP (ferrocenyl oxazolinylphosphine) complex was developed, affording 2,5-dihydropyrrole derivatives in good to excellent yields (up to 99%) and excellent levels of enantioselectivities (up to 98% ee). This highly efficient chiral N,P-ligand/Cu(OAc)2 catalytic system was also applicable for the 1,3-dipolar cycloaddition of α-arylglycine ester-generated azomethine ylides to ynones, affording exclusive quaternary carbon-containing cis-2,5-dihydropyrroles in excellent enantioselectivities (89–92% ee).
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Journal Name：Catalysis Science & Technology
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CAS no.: 89640-58-4
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