Catalytic asymmetric 1,6-conjugate addition of in situ generated para-quinone methides with tritylthiol?
Organic Chemistry Frontiers Pub Date: 2018-04-24 DOI: 10.1039/C8QO00211H
Abstract
An asymmetric phase-transfer catalyzed 1,6-conjugate addition of in situ generated para-quinone methides (p-QMs) with tritylthiol has been developed, affording a range of optically active α-substituted benzyl thioethers in excellent yields (up to 98%) and enantioselectivities (up to 97% ee). The use of 4-hydroxybenzyl p-tolyl sulfones as precursors for the formation of p-QMs allows one to overcome the limitations in the substrate scope.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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